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Clozapine was first shown to be superior to chlorpromazine (Thorazine) in patients who had inadequate response to at least 3 first-generation antipsychotics (Kane J et al, Arch Gen Psych 1988;45(9):789796)

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Warning labels with explicit images of cancerous lungs, increasing sales taxes, and near blanket prohibitions of smoking in public spaces are now all commonplace in many nations across the globe.[2] But across much of the world during the much of the 19th and early 20th centuries, public and medical opinion on cigarettes and their impact on health was more or less the opposite